Extracellular [K+] fluctuations in voltage-clamped canine cardiac Purkinje fibers
نویسندگان
چکیده
منابع مشابه
Extracellular [K+] fluctuations in voltage-clamped canine cardiac Purkinje fibers.
Membrane currents and extracellular [K+] were measured in canine Purkinje strands during voltage-clamp steps to plateau or diastolic potentials. Extracellular [K+] increased during step depolarizations and decreased during step hyperpolarizations. On hyperpolarization, the largest fraction of the K+ depletion occurred during the initial 500 ms of the voltage-clamp step and was correlated with a...
متن کاملCanine Purkinje Fibers
and glucocorticoid excretory responses to alpha 1-24 ACTH (Cortrosyn) in sodium-deplctcd normal man. J Clin Endocrinol Mctab 36: 30-35, 1973 14. Sncdccor GW. Cochran WG Statistical Methods, ed 6. Ames, Iowa State University Press, 1969, p 246 15. Dunnett CW: New tables for multiple comparisons with a control. Biometrics 20: 482-491, 1964 16 Laragh JH: Vasoconstnction-volume analysis for underst...
متن کاملCanine Purkinje Fibers
Developmental changes in the cardiac effects of antiarrhythmic drugs have been noted in the clinical setting. To study whether these might in part be based on developmental differences in drug effects on the transmembrane potential, we used standard microelectrode techniques to study the effects of lidocaine on the transmembrane potentials of Purkinje fibers from adult and young dogs. Control s...
متن کاملMembrane current following activity in canine cardiac Purkinje fibers
Membrane current following prolonged periods of rapid stimulation was examined in short (less than 1.5 mm) canine cardiac Purkinje fibers of radius less than 0.15 mm. The Purkinje fibers were repetitively stimulated by delivering trains of depolarizing voltage clamp pulses at rapid frequencies. The slowly decaying outward current following repetitive stimulation ("post-drive" current) is elimin...
متن کاملMicroelectrode demonstration of Wedensky facilitation in canine cardiac Purkinje fibers.
Microelectrode techniques were used to examine changes in excitability of canine Purkinje fibers at sites distal to complete conduction block. Immediately distal to a site where impulse propagation failed, it was possible to record subthreshold depolarizations. Intracellular stimulation of the Purkinje cells exhibiting these subthreshold responses with constant-current pulses of subthreshold in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1984
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(84)84065-5